The RCMP called to a single vehicle collision on Highway 1 westbound in the Pennfield/Pocologan area.
It happened just before 7 yesterday morning and one lane of the highway was blocked.
Horizon Health confirming to Tide News that five people were rushed to the Regional Hospital.
One car could be seen flipped over on its roof in the ditch.
The Mounties have not released any information about whether anyone died in the crash